TAOK1 Antibody - #DF4476
Product: | TAOK1 Antibody |
Catalog: | DF4476 |
Description: | Rabbit polyclonal antibody to TAOK1 |
Application: | WB IHC IF/ICC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
Mol.Wt.: | 120 KD; 116kD(Calculated). |
Uniprot: | Q7L7X3 |
RRID: | AB_2836827 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4476, RRID:AB_2836827.
Fold/Unfold
2810468K05Rik; AU020252; D130018F14Rik; EC 2.7.11.1; FLJ14314; hKFC B; hKFC-B; KIAA1361; Kinase from chicken homolog B; MAP3K16; MARK kinase; MARKK; MGC29021; Microtubule affinity regulating kinase kinase; mKIAA1361; Prostate-derived sterile 20-like kinase 2; PSK2; Serine/threonine kinase TAO1; Serine/threonine protein kinase TAO1; Serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20 like kinase; STE20 like kinase PSK2; STE20-like kinase PSK2; TAO kinase 1; Taok1; TAOK1_HUMAN; Thousand and one amino acid protein 1;
Immunogens
Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
- Q7L7X3 TAOK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7L7X3 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S9 | Phosphorylation | Uniprot | |
K21 | Ubiquitination | Uniprot | |
Y43 | Phosphorylation | Uniprot | |
S66 | Phosphorylation | Uniprot | |
K84 | Ubiquitination | Uniprot | |
Y107 | Phosphorylation | Uniprot | |
S181 | Phosphorylation | Uniprot | |
T185 | Phosphorylation | Uniprot | |
R269 | Methylation | Uniprot | |
Y309 | Phosphorylation | Uniprot | |
Y406 | Phosphorylation | Uniprot | |
S417 | Phosphorylation | Uniprot | |
S421 | Phosphorylation | Uniprot | |
S426 | Phosphorylation | Uniprot | |
Y432 | Phosphorylation | Uniprot | |
T440 | Phosphorylation | Uniprot | |
S445 | Phosphorylation | Uniprot | |
S458 | Phosphorylation | Uniprot | |
T480 | Phosphorylation | Uniprot | |
T502 | Phosphorylation | Uniprot | |
K546 | Acetylation | Uniprot | |
S554 | Phosphorylation | Uniprot | |
T576 | Phosphorylation | Uniprot | |
K587 | Ubiquitination | Uniprot | |
Y610 | Phosphorylation | Uniprot | |
T643 | Phosphorylation | Q13315 (ATM) | Uniprot |
T669 | Phosphorylation | Uniprot | |
S714 | Phosphorylation | Uniprot | |
K718 | Ubiquitination | Uniprot | |
T734 | Phosphorylation | Uniprot | |
K750 | Ubiquitination | Uniprot | |
T785 | Phosphorylation | Q13315 (ATM) | Uniprot |
K818 | Ubiquitination | Uniprot | |
S965 | Phosphorylation | Uniprot | |
S974 | Phosphorylation | Uniprot | |
S987 | Phosphorylation | Uniprot | |
S990 | Phosphorylation | Q13315 (ATM) | Uniprot |
S993 | Phosphorylation | Uniprot | |
T1001 | Phosphorylation | Uniprot |
PTMs - Q7L7X3 As Enzyme
Research Backgrounds
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Proteolytically processed by caspase-3 (CASP3).
Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.
Cytoplasm.
Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.