Product: STOML1 Mouse Monoclonal Antibody
Catalog: BF8923
Description: Mouse monoclonal antibody to STOML1
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 50kD; 43kD(Calculated).
Uniprot: Q9UBI4

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Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8923]
Specificity:
STOML1 Mouse Monoclonal Antibody detects endogenous levels of STOML1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

EPB72 like 1; hUNC 24; SLP 1; SLP1; Stomatin (EBP72) like 1; Stomatin related protein; STORP; UNC24;

Immunogens

Immunogen:

A synthesized peptide derived from human STOML1.

Uniprot:
Gene(ID):
Expression:
Q9UBI4 STML1_HUMAN:

Ubiquitously expressed at low levels. Expression is highest in brain.

Sequence:
MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGADVPQSWPSCLCHGLISFLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTTGRGRVGHGVPDGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLRALK

Research Backgrounds

Function:

May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation.

Subcellular Location:

Membrane>Single-pass type III membrane protein. Late endosome membrane. Membrane raft. Cell membrane>Single-pass type III membrane protein. Cytoplasmic vesicle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed at low levels. Expression is highest in brain.

Subunit Structure:

Interacts with STOM; may redistribute STOM from the plasma membrane to late endosomes. Interacts with FBXW7 isoform 3 and CDK2.

Family&Domains:

Belongs to the band 7/mec-2 family.

Restrictive clause

 

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