Product: Peroxiredoxin 5 Mouse Monoclonal Antibody
Catalog: BF8849
Description: Mouse monoclonal antibody to Peroxiredoxin 5
Application: WB
Reactivity: Human
Prediction: Mouse, Rat, Pig, Zebrafish, Bovine, Horse, Sheep, Xenopus
Mol.Wt.: 17 kDa; 22kD(Calculated).
Uniprot: P30044

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8849]
Specificity:
Peroxiredoxin 5 Mouse Monoclonal Antibody detects endogenous levels of total Peroxiredoxin 5.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ACR1; Alu co repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; B166; epididymis secretory protein Li 55; HEL-S-55; Liver tissue 2D-page spot 71B; mitochondrial; Peroxiredoxin 5, mitochondrial; Peroxiredoxin V; Peroxiredoxin-5; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX 5; PRDX5; PRDX5_HUMAN; PRDX6; Prx-V; PRXV; SBBI10; Thioredoxin peroxidase PMP20; Thioredoxin reductase; TPx type VI;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P30044 PRDX5_HUMAN:

Widely expressed.

Sequence:
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL

PTMs - P30044 As Substrate

Site PTM Type Enzyme
S34 Phosphorylation
K75 Ubiquitination
K83 Acetylation
K83 Ubiquitination
K86 Ubiquitination
T97 Phosphorylation
C100 S-Nitrosylation
S101 Phosphorylation
K102 Ubiquitination
K116 Ubiquitination
K118 Ubiquitination
K146 Ubiquitination
K159 Ubiquitination
S182 Phosphorylation

Research Backgrounds

Function:

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Subcellular Location:

Mitochondrion.

Cytoplasm. Peroxisome matrix.
Note: Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed.

Subunit Structure:

Monomer.

Family&Domains:

Belongs to the peroxiredoxin family. Prx5 subfamily.

Research Fields

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

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