Product: TMOD1 Mouse Monoclonal Antibody
Catalog: BF8843
Description: Mouse monoclonal antibody to TMOD1
Application: WB
Reactivity: Human
Prediction: Mouse, Rat, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 41 kDa; 41kD(Calculated).
Uniprot: P28289

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 100ul $280 In stock
 200ul $350 In stock

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Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8843]
Specificity:
TMOD1 Mouse Monoclonal Antibody detects endogenous levels of total TMOD1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

D9S57E; E Tmod; E tropomodulin; E-Tmod; Erythrocyte tropomodulin; ETMOD; MGC124125; MGC124126; OTTHUMP00000021743; TMOD; Tmod1; TMOD1 protein; TMOD1_HUMAN; Tropomodulin 1; Tropomodulin-1;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P28289 TMOD1_HUMAN:

Highly expressed in the erythrocyte, heart and skeletal muscle.

Sequence:
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV

PTMs - P28289 As Substrate

Site PTM Type Enzyme
S2 Phosphorylation Q96QT4 (TRPM7)
Y3 Phosphorylation
Y10 Phosphorylation
T23 Phosphorylation
T54 Phosphorylation Q96QT4 (TRPM7)
Y87 Phosphorylation
Y225 Phosphorylation
T234 Phosphorylation
S236 Phosphorylation
Y242 Phosphorylation
Y278 Phosphorylation
S329 Phosphorylation

Research Backgrounds

Function:

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Subcellular Location:

Cytoplasm>Cytoskeleton.
Note: In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in the erythrocyte, heart and skeletal muscle.

Subunit Structure:

Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.

Family&Domains:

Belongs to the tropomodulin family.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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