Product: SCML2 Mouse Monoclonal Antibody
Catalog: BF8651
Description: Mouse monoclonal antibody to SCML2
Application: WB
Reactivity: Human
Prediction: Mouse
Mol.Wt.: 70,90 kDa; 77kD(Calculated).
Uniprot: Q9UQR0

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Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm8651]
Specificity:
SCML2 Mouse Monoclonal Antibody detects endogenous levels of total SCML2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

SCML2; SCML2_HUMAN; sex comb on midleg like 2 (Drosophila); Sex comb on midleg like 2; Sex comb on midleg like protein 2; Sex comb on midleg, Drosophila, homolog-like 2; Sex comb on midleg-like protein 2;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9UQR0 SCML2_HUMAN:

Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.

Sequence:
MGQTVNEDSMDVKKENQEKTPQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQSPQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSPHEVKFQMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS

PTMs - Q9UQR0 As Substrate

Site PTM Type Enzyme
S9 Phosphorylation
K13 Sumoylation
K19 Ubiquitination
T20 Phosphorylation
K40 Ubiquitination
K64 Ubiquitination
K68 Ubiquitination
K123 Methylation
K161 Sumoylation
K162 Ubiquitination
K177 Sumoylation
K177 Ubiquitination
K184 Sumoylation
K184 Ubiquitination
K248 Ubiquitination
K252 Sumoylation
T253 Phosphorylation
S255 Phosphorylation
S256 Phosphorylation
S258 Phosphorylation
S261 Phosphorylation
S264 Phosphorylation
S267 Phosphorylation
K296 Acetylation
S299 Phosphorylation
S300 Phosphorylation
K302 Ubiquitination
T305 Phosphorylation P24941 (CDK2) , P06493 (CDK1)
K318 Sumoylation
T326 Phosphorylation
K332 Ubiquitination
K343 Ubiquitination
K374 Ubiquitination
K407 Acetylation
K482 Acetylation
K487 Sumoylation
S495 Phosphorylation
T496 Phosphorylation
S499 Phosphorylation
T503 Phosphorylation
Y506 Phosphorylation
S511 Phosphorylation P24941 (CDK2) , P06493 (CDK1)
K518 Ubiquitination
Y520 Phosphorylation
S522 Phosphorylation
K536 Sumoylation
K536 Ubiquitination
K545 Sumoylation
K545 Ubiquitination
T567 Phosphorylation
S568 Phosphorylation
S570 Phosphorylation
S576 Phosphorylation
T581 Phosphorylation
S582 Phosphorylation
S583 Phosphorylation
S590 Phosphorylation P06493 (CDK1) , P24941 (CDK2)
S593 Phosphorylation
S594 Phosphorylation
K599 Sumoylation
K599 Ubiquitination
K605 Sumoylation
K605 Ubiquitination
S606 Phosphorylation
K621 Ubiquitination
K663 Ubiquitination
S670 Phosphorylation
K680 Sumoylation

Research Backgrounds

Function:

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.

Family&Domains:

Belongs to the SCM family.

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