FBXO25 Antibody - #DF14736
Product: | FBXO25 Antibody |
Catalog: | DF14736 |
Description: | Rabbit polyclonal antibody to FBXO25 |
Application: | ELISA(peptide) |
Reactivity: | Human, Mouse, Rat |
Mol.Wt.: | 43kD(Calculated). |
Uniprot: | Q8TCJ0 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; FBX25_HUMAN; FBXO25; MGC20256; MGC51975; OTTHUMP00000115399;
Immunogens
A synthesized peptide derived from human FBXO25.
- Q8TCJ0 FBX25_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNRCNISHSIILNSEDGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNILYRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMYFALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPDSCFTPVSPQHFIDLFKF
Research Backgrounds
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).
Nucleus.
Note: In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Expressed in all brain tissue observed.
Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).
The F-box is necessary for the interaction with SKP1.
Research Fields
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
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