SLC17A5 Antibody - #DF14632
| Product: | SLC17A5 Antibody |
| Catalog: | DF14632 |
| Description: | Rabbit polyclonal antibody to SLC17A5 |
| Application: | ELISA(peptide) |
| Reactivity: | Human |
| Mol.Wt.: | 55kD(Calculated). |
| Uniprot: | Q9NRA2 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
AST; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; ISSD; Membrane glycoprotein HP59; NSD; S17A5_HUMAN; SD; Sialic acid storage disease; Sialin; SIASD; Slc17a5; SLD; Solute carrier family 17 (anion/sugar transportermember 5; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporter;
Immunogens
A synthesized peptide derived from human SLC17A5.
Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
- Q9NRA2 S17A5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
Research Backgrounds
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
Cell membrane>Multi-pass membrane protein. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle membrane>Multi-pass membrane protein. Lysosome membrane>Multi-pass membrane protein.
Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Research Fields
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
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