alpha 1 Spectrin Antibody - #DF13417
Product: | alpha 1 Spectrin Antibody |
Catalog: | DF13417 |
Description: | Rabbit polyclonal antibody to alpha 1 Spectrin |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Horse |
Mol.Wt.: | 280kDa, 110 kDa; 280kD(Calculated). |
Uniprot: | P02549 |
RRID: | AB_2846436 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13417, RRID:AB_2846436.
Fold/Unfold
Alpha I spectrin; EL 2; EL2; Elliptocytosis 2; Elliptocytosis2; Erythrocyte alpha spectrin; erythrocyte; Erythroid alpha spectrin; Erythroid alpha-spectrin; Erythroid spectrin alpha; HPP; HS3; Spectrin alpha chain; Spectrin alpha chain erythrocyte; Spectrin alpha erythrocytic 1; SPH3; SPTA 1; SPTA; SPTA1; SPTA1_HUMAN;
Immunogens
- P02549 SPTA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P02549 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S37 | Phosphorylation | Uniprot | |
K59 | Acetylation | Uniprot | |
S96 | Phosphorylation | Uniprot | |
S261 | Phosphorylation | Uniprot | |
K283 | Acetylation | Uniprot | |
S299 | Phosphorylation | Uniprot | |
S317 | Phosphorylation | Uniprot | |
Y370 | Phosphorylation | Uniprot | |
Y422 | Phosphorylation | Uniprot | |
S507 | Phosphorylation | Uniprot | |
S510 | Phosphorylation | Uniprot | |
Y548 | Phosphorylation | Uniprot | |
Y588 | Phosphorylation | Uniprot | |
T635 | Phosphorylation | Uniprot | |
T812 | Phosphorylation | Uniprot | |
S818 | Phosphorylation | Uniprot | |
S844 | O-Glycosylation | Uniprot | |
Y986 | Phosphorylation | Uniprot | |
S992 | Phosphorylation | Uniprot | |
Y1064 | Phosphorylation | Uniprot | |
S1167 | Phosphorylation | Uniprot | |
S1250 | O-Glycosylation | Uniprot | |
T1257 | Phosphorylation | Uniprot | |
S1284 | Phosphorylation | Uniprot | |
S1363 | Phosphorylation | Uniprot | |
S1424 | Phosphorylation | Uniprot | |
S1425 | Phosphorylation | Uniprot | |
S1428 | Phosphorylation | Uniprot | |
K1486 | Ubiquitination | Uniprot | |
Y1499 | Phosphorylation | Uniprot | |
Y1538 | Phosphorylation | Uniprot | |
K1579 | Acetylation | Uniprot | |
K1586 | Acetylation | Uniprot | |
S1738 | O-Glycosylation | Uniprot | |
K1803 | Ubiquitination | Uniprot | |
S1901 | Phosphorylation | Uniprot | |
T1910 | Phosphorylation | Uniprot | |
S1912 | Phosphorylation | Uniprot | |
S1976 | Phosphorylation | Uniprot | |
K2051 | Acetylation | Uniprot | |
K2200 | Acetylation | Uniprot | |
S2269 | Phosphorylation | Uniprot | |
T2288 | Phosphorylation | Uniprot | |
Y2333 | Phosphorylation | Uniprot | |
S2335 | Phosphorylation | Uniprot | |
S2405 | Phosphorylation | Uniprot | |
Y2407 | Phosphorylation | Uniprot |
Research Backgrounds
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Cytoplasm>Cytoskeleton. Cytoplasm>Cell cortex.
Composed of non-homologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Interacts with FASLG.
Belongs to the spectrin family.
Research Fields
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
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