GDF8 / Myostatin Antibody - #DF13273
| Product: | GDF8 / Myostatin Antibody |
| Catalog: | DF13273 |
| Description: | Rabbit polyclonal antibody to GDF8 / Myostatin |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat, Sheep |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 42kDa, (precursor)72 kDa; 43kD(Calculated). |
| Uniprot: | O14793 |
| RRID: | AB_2846292 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13273, RRID:AB_2846292.
Fold/Unfold
GDF 8; GDF-8; GDF8; GDF8_HUMAN; Growth differentiation factor 8; Growth/differentiation factor 8; MSLHP; MSTN; Myostatin; OTTHUMP00000163498;
Immunogens
- O14793 GDF8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14793 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S62 | Phosphorylation | Uniprot |
Research Backgrounds
Acts specifically as a negative regulator of skeletal muscle growth.
Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Secreted.
Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
Belongs to the TGF-beta family.
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