HES6 Antibody - #DF8664
| Product: | HES6 Antibody |
| Catalog: | DF8664 |
| Description: | Rabbit polyclonal antibody to HES6 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Bovine |
| Mol.Wt.: | 24kDa,27kDa; 24kD(Calculated). |
| Uniprot: | Q96HZ4 |
| RRID: | AB_2841868 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8664, RRID:AB_2841868.
Fold/Unfold
bHLHb41; bHLHc23; C HAIRY1; Class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; Hairy/enhancer of split 6, Drosophila, homolog of, 6; HES 6; hes family bHLH transcription factor 6; Transcription cofactor HES6;
Immunogens
- Q96HZ4 HES6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96HZ4 As Substrate
Research Backgrounds
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Nucleus.
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with HES1 (By similarity).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Research Fields
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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